Plasma substance P levels in patients with persistent cough.

نویسندگان

  • Kojiro Otsuka
  • Akio Niimi
  • Hisako Matsumoto
  • Isao Ito
  • Masafumi Yamaguchi
  • Hirofumi Matsuoka
  • Makiko Jinnai
  • Tsuyoshi Oguma
  • Tomoshi Takeda
  • Hitoshi Nakaji
  • Kazuo Chin
  • Kazuhiko Sasaki
  • Norihito Aoyama
  • Michiaki Mishima
چکیده

BACKGROUND Substance P (SP) is involved in the pathogenesis of cough in animal models. However, few studies in humans have been reported and the roles of SP in clinical cough remain obscure. OBJECTIVES To clarify the relevance of plasma levels of SP in patients with persistent cough. METHODS We studied 82 patients with cough persisting for at least 3 weeks and 15 healthy controls. Patients were classified as having asthmatic cough (cough-variant asthma and cough-predominant asthma; n = 61) or nonasthmatic cough (n = 21; postinfectious cough, n = 6; gastroesophageal reflux disease, n = 5; idiopathic cough, n = 5, and others, n = 5). Correlations were evaluated between plasma SP levels as measured with ELISA and methacholine airway hyperresponsiveness (airway sensitivity and airway reactivity), capsaicin cough sensitivity, sputum eosinophil and neutrophil counts, and pulmonary function. RESULTS Plasma SP levels were significantly elevated in patients with both asthmatic and nonasthmatic cough compared with controls [31.1 pg/ml (range 18.0-52.2) and 30.0 pg/ml (range 15.1-50.3) vs. 15.4 pg/ml (range 11.3-23.7); p = 0.003 and p = 0.038, respectively] but did not differ between the two patient groups (p = 0.90). Plasma SP levels correlated with airway sensitivity (threshold dose of methacholine) in the patients with asthmatic cough (r = -0.37, p = 0.005) but not with airway reactivity, cough sensitivity, FEV1 values, or sputum eosinophil and neutrophil counts in either group. CONCLUSIONS Increased levels of SP in plasma are associated with persistent cough in humans and might be related to airway sensitivity in asthmatic cough.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی اثر خون اتولوگ برای پلورودز در نشت مداوم هوا (Persistent air leak)، دانشگاه علوم پزشکی گیلان، 80-1377

Persistent air leaks occur after Spontaneous pneumothorax both primary and secondary, and after lungs trauma and lung surgeries are sever problems encountered chest surgeons with. Persistent air leak causes longer patients hospitalization.Materials and Methods: We used autologous blood pleurodesis in patients with persistent air leak for 30patients with more than 8 days air leaks, during a thre...

متن کامل

بررسی اثر خون اتولوگ برای پلورودز در نشت مداوم هوا (Persistent air leak)، دانشگاه علوم پزشکی گیلان، 80-1377

Persistent air leaks occur after Spontaneous pneumothorax both primary and secondary, and after lungs trauma and lung surgeries are sever problems encountered chest surgeons with. Persistent air leak causes longer patients hospitalization.Materials and Methods: We used autologous blood pleurodesis in patients with persistent air leak for 30patients with more than 8 days air leaks, during a thre...

متن کامل

بررسی اثر خون اتولوگ برای پلورودز در نشت مداوم هوا (Persistent air leak)، دانشگاه علوم پزشکی گیلان، 80-1377

Persistent air leaks occur after Spontaneous pneumothorax both primary and secondary, and after lungs trauma and lung surgeries are sever problems encountered chest surgeons with. Persistent air leak causes longer patients hospitalization.Materials and Methods: We used autologous blood pleurodesis in patients with persistent air leak for 30patients with more than 8 days air leaks, during a thre...

متن کامل

بررسی اثر خون اتولوگ برای پلورودز در نشت مداوم هوا (Persistent air leak)، دانشگاه علوم پزشکی گیلان، 80-1377

Persistent air leaks occur after Spontaneous pneumothorax both primary and secondary, and after lungs trauma and lung surgeries are sever problems encountered chest surgeons with. Persistent air leak causes longer patients hospitalization.Materials and Methods: We used autologous blood pleurodesis in patients with persistent air leak for 30patients with more than 8 days air leaks, during a thre...

متن کامل

بررسی اثر خون اتولوگ برای پلورودز در نشت مداوم هوا (Persistent air leak)، دانشگاه علوم پزشکی گیلان، 80-1377

Persistent air leaks occur after Spontaneous pneumothorax both primary and secondary, and after lungs trauma and lung surgeries are sever problems encountered chest surgeons with. Persistent air leak causes longer patients hospitalization. Materials and Methods: We used autologous blood pleurodesis in patients with persistent air leak for 30patients with more than 8 days air leaks, during a th...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Respiration; international review of thoracic diseases

دوره 82 5  شماره 

صفحات  -

تاریخ انتشار 2011